Drug Penetration Enhancement Techniques in Transdermal Drug Delivery System: A Review

Transdermal Drug Delivery System (TDDS) is described as a self-contained or discrete dosage form that applied to the intact skin. This rout of drug administration drugs through skin for therapeutic use an alternative approach oral, intravascular, subcutaneous, and transmucosal routes. The delivery systemic circulation provides convenient route variety clinical indications. allows continuous administration, with short biological half lives, avoids increases hepatic first pass elimination rapid termination medication by removing transdermal system from Various technologies may be different categories pharmaceuticals used treatment disorders effects treat diseases other organs. Several products applications include hormone replacement therapy, contraception, pain management, angina pectoris, smoking cessation, neurological such Parkinson's disease. most commonly patch using various types technologies. Stratum corneum outermost layer it main barrier permeation in drugs. So, circumvent properties stratum increase flux membrane penetration enhancement techniques are system. review presents physical chemical methods approaches optimize